I'm pretty much doing these exclusively in Photoshop now. It maintains the immediacy and energy of the original rough sketch, and allows me to experiment more with color and layering. I can't say enough about using layers in Photoshop. You can add and adjust tints & hues, make physical adjustments to your drawings, and it's a fail safe fallback just in case you screw up (which I do often).
Oh well, as my Dad used to say "keep that kid away from the crayons!"